early appearance in the urine and the rapidity and completeness of its elimination by the kidney and the reliance to be placed on its findings. 3. The method of quantitative estimation of the amount of drug excreted is simple and exceedingly accurate. •I. If is of immense value from a diagnostic and prognostic standpoint in nephritis, inasmuch as it reveals the degree of functional derangement in nephritis whether of the acute or chronic variety.