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Quantifying the influence of mutation detection on tumour subclonal reconstruction
2020
Nature Communications
AbstractWhole-genome sequencing can be used to estimate subclonal populations in tumours and this intra-tumoural heterogeneity is linked to clinical outcomes. Many algorithms have been developed for subclonal reconstruction, but their variabilities and consistencies are largely unknown. We evaluate sixteen pipelines for reconstructing the evolutionary histories of 293 localized prostate cancers from single samples, and eighteen pipelines for the reconstruction of 10 tumours with multi-region
doi:10.1038/s41467-020-20055-w
pmid:33288765
fatcat:g6ayrcoojncydj6pi3kxu55wsm