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Designing refoldable model molecules
2003
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics
We report a numerical study of the design of lattice heteropolymers that can refold when the properties of only a few monomers are changed. If we assume that the effect of an external agent on a heteropolymer is to alter the interactions between its constituent monomers, our simulations provide a description of a simple allosteric transition. We characterize the free energy surfaces of the initial and the modified chain molecule. We find that there is a region of conformation space where
doi:10.1103/physreve.68.046703
pmid:14683075
fatcat:amyl2e2xwff4dpxwjeqyiq3cei