Synthesis and Study of 1,2,4-Oxadiazolines derivatives and their Antifungal activity

Kumar Gaurav Jain, C. P. Singh
2016 IOSR Journal of Applied Chemistry  
Addition of benzonitrileoxide,generatedin situ by the action of triethylamine on benzhydoxamoyl chloride, to 2-hydroxybenzalaniline and its N-phenyl derivatives yielded a mixture of products which was separated into two compounds by fractional crystallization. The major products have been found to be the respective cycloadducts and the minor product was identified as the dimer of the starting nitrile oxide. The cycloadducts have been identified as 1,2,4-oxadiazoline derivatives (Ia-Va) on the
more » ... sis of elemental analysis and spectral studies. The synthesized 1,2,4-oxadiazolines (Ia-Va) were tested in vitro for their antifungal activity against Alternaria alternate, Curvularialunata, Fusariumoxysporumand Myrotheciumroridum by employing the standard technique of spore germination inhibition at various concentrations. Some of the compounds have shown promising antifungal activity against the test fungi. Synthesis and Study of 1,2,4-Oxadiazolines derivatives and their antifungal activity.
doi:10.9790/5736-0909015254 fatcat:dcgpgvwz6fhwtd5klllk7rbdvi