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Encyclopedia of Exercise Medicine in Health and Disease
Ubiquitination is a widespread posttranslational modification of a protein that usually requires the sequential action of the ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitinprotein ligase (E3), which recognizes a subset of specific substrates. Polyubiquitination targets protein substrates for breakdown by the 26 S proteasome. By contrast, mono-, di-, and tri-ubiquitination are not degradation signals but have several signaling roles within the cells.doi:10.1007/978-3-540-29807-6_3154 fatcat:xcdg2opgnbga7brsgxgah5gpvi