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BRG1/BRM-associated factor complex subunit diversity promotes temporally distinct gene expression programs in cardiogenesis
[article]
2017
bioRxiv
pre-print
Chromatin remodeling complexes instruct cellular differentiation and lineage specific transcription. However, the underlying mechanism is unclear. Here, using immunoprecipitation with mass spectrometry (IP-MS), we determined the dynamic composition of the BRG1/BRM associated factor (BAF) complexes during mammalian cardiac differentiation, and identified BAF60c (SMARCD3) and BAF170 (SMARCC2) as subunits enriched in cardiac precursors (CP) and cardiomyocytes (CM). The catalytic subunit Brg1 has a
doi:10.1101/166983
fatcat:7nvsowlk6jhutk5uiwumy6diiu