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Obesity and Breast Cancer: Progress to Understanding the Relationship
2009
Cancer Research
Epidemiological evidence supports a correlation between obesity and breast cancer in women. AMP-activated protein kinase (AMPK) is recognized to be a master regulator of energy homeostasis. One of its actions is to phosphorylate and inhibit the actions of cAMP-responsive element binding protein (CREB)-regulated transcription coactivator 2 (CRTC2). In postmenopausal women, the CREB-dependent regulation of aromatase is a crucial determinant of breast tumor formation through local production of
doi:10.1158/0008-5472.can-09-2257
pmid:20028864
fatcat:iwp63jcrzndpfdlpahuikasi3u