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Neuromuscular Disease: A Case-Based Approach
Keywords Name of disease and synonyms Name of excluded diseases Diagnostic criteria / definition Differential diagnosis Frequency Clinical description Management including treatment Etiology Diagnosis Unresolved questions References Abstract Primary lateral sclerosis (PLS) is an idiopathic non-familial neurodegenerative disorder of upper motor neurons, presenting as a slowly progressive pyramidal tract syndrome. Disease onset is usually between 40 and 60 years with spasticity in the legs. Onsetdoi:10.1017/cbo9780511735905.005 fatcat:rt4tta3kavck5kexjlk6eqx4mq