Clinical and Experimental Studies on Diabetic Renal Disorder

1960 Folia Endocrinologica Japonica  
Control of diabetes mellitus in recent years has become less difficult even with complicated with infection, however, the general vascular disorders, especially diabetic nephropathy, as a result of long standing metabolic disturbance will present a serious problem in the prognosis of diabetes. In spite of voluminous reports on the subject appearing in foreign countries, our domestic reports have been limited to a few. Present investigation is the report on the behaviours of renal circulation
more » ... glucose reabsorption from renal tubules by means of measuring renal plasma flow (RPF), renal blood flow (RBF), glomerular filtration rate (GFR) and tubular reabsorptive mass (TmG) in 50 diabetic patients. Then an attempt was made to analize the relations between these findings with sex, age, severity, duration of the disorder, blood pressure, proteinuria, retinal finding and insulin sensitivity. In addition, renal biopsy was carried out on some of 50 diabetic cases. With the methods mentioned above diagnosis, severity, prognosis and etiology of the renal disorders have been studied. In brief, the disorders could be classified into three groups from the view point of glomerular function. 1. A group with normal glomerular function. (with RPF. 410-600 ml/min, including cases with GFR over 90 ml/min and RPF between 400-410 ml/min) Among these cases, 58 percent belonged to this group. Many of them showed a short history of the disease with normal insulin sensitivity, negative proteinuria, normal blood pressure except a few cases of slight hypertension, and normal ophthalmoscopic finding except two cases which showed either high normal value or high value in TmG. Extremely high value of TmG were encountered in the cases of severe and moderately advanced diabetics. The GFR/TmG ratio showed low value in large number. 2. A group with glomerular hyperfunction. (with RPF over 600 ml/min) Among these cases 16 percent belonged to this group. These cases were usually juvenile diabetics
doi:10.1507/endocrine1927.36.4_641 fatcat:vcv6oyx7hfbsdk6id5gf2fe4cq