Quality Improvement Programs Improve Recognition, Early Treatment and Outcome of Pediatric Septic Shock

B Klein, K Choong, L Huang
2009 Paediatrics & child health  
Questionnaire (MSQ). Safety assessments of AEs were included. Changes from baseline in ADHD-RS-IV (primary) and EESC/BRIEF (post hoc) scores were analyzed by 1-sample t-test. CGI-I and PGA scores were dichotomized into improved (score=1 or 2) vs not improved (score ≥3). RESULTS: At endpoint, overall percent (SD) improvement in ADHD-RS-IV total score from baseline was 69.3% (23.3) (P<.0001; intent-totreat population, N=316). Most subjects improved, based on CGI-I (89.9%; 61.7% very much improved
more » ... and 28.2% much improved) and PGA (85.0%; 40.8% very much improved and 44.3% much improved). Improvement was seen on EESC mean total, positive emotions, emotional flatness, and lability subscale scores (P≤.001). Scores on BRIEF also indicated improvement on the global executive composite, behavioral regulation, and metacognition scales (P<.0001). MSQ scores indicated most parents (76.0%) were very satisfied, 21.1% were moderately satisfied, 2.3% were not satisfied with LDX treatment, and 0.6% didn't know. Treatment-emergent AEs in ≥10% of subjects were decreased appetite, decreased weight, irritability, insomnia, headache, upper abdominal pain, and initial insomnia. CONCLUSIONS: LDX was effective as assessed by both parents and investigators when dosed from 20 to 70 mg/d. There was overall improvement in ADHD symptoms and executive function scores with no worsening of mean emotional expression scores as measured by EESC. Most parents were very satisfied with LDX treatment. LDX was generally well tolerated.
doi:10.1093/pch/14.suppl_a.17a fatcat:blnupkzvkfclfkjcf7af4c4f3a