Serum protein electrophoresis (SPE) is usually ordered to diagnose multiple myeloma (MM). Although levels of proteins in the serum change in predictable way in response to different clinical situations that can be detected from SP bands on a gel; people tend to use other multiple laboratory tests. 44 patient's samples negative for MM were analyzed using automatic agarose gel electrophoresis system/compact Microgel Interlab. Readings for bands were compared to each other's and compared to

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... /globulin ratio (G/A). Bands studied showed 14 cases with polyclonal bands, one with sign of hemolysis, other hyperlipidemia, and one with low serum globulin. All bands showed significant positive correlation with A/G except for α2 negative correlation; p<0.05. SPE can predict clinical situation other than MM when used with trained personnel.