Formulation and in vitro characterization of tapentadol HCL as immediate release tablets

Paramasivam Suresh Kumar, Batlanki Priyanka, Vemula Sindhu, Varanasi Jagannath Patro, T Praveen Kumar, Syed Yasmin Sulthana
2018 GSC Biological and Pharmaceutical Sciences  
The aim of the present study is to develop and evaluate the immediate release tablet of tapentadol by direct compression method. The superdisintegrant explotab, solutab and polyplasdoneXL were used for immediate release of drug from tablet. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug-excipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. The study reveals that
more » ... ions prepared by direct compression F2 exhibits highest dissolution using explotab showed faster drug release 95.48 % over the period of 45 min while disintegration time of the tablet was showed 12 sec in comparison to other formulations of tapentadol.
doi:10.30574/gscbps.2018.4.3.0072 fatcat:c6iac5u7gbgofme4ep76gsm73e