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The aging of female reproductive system is mainly manifested by the decline of ovarian function, which is a physiological phenomenon. When it happens prematurely, it is called premature ovarian insufficiency(POI). Huyang Yangkun Formula(HYYKF) was developed according to theory of Chinese medicine and clinical experience and found to obviously relieve symptoms associated with menopause in POI patients. However, little is known about the effect of HYYKF on N6-methyladenosine (m 6 A) modificationdoi:10.21203/rs.3.rs-28742/v1 fatcat:6mbbenvcybeutmprpk3ges5xiq