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Contribution of the Leishmania P-glycoprotein-related gene ltpgpA to oxyanion resistance
Journal of Biological Chemistry
Oxyanions in the form of pentavalent antimony compounds are currently the drug of choice for treating leishmaniasis. Leishmania mutants resistant to high concentrations of the oxyanion arsenite were obtained in a stepwise selection procedure. Amplification of the H locus P-glycoprotein-related gene ltpgpA, as part of extrachromosomal circles, is a frequent event in arsenite-resistant cells, but was observed only in cells resistant to high concentrations of the metalloid salts. Revertants grownpmid:7909316 fatcat:pqj4wlsx7jbetjsjkqxal3sooa