Are fat oxidation and cardiorespiratory adaptations impaired during exercise in untreated non-obese severe obstructive sleep apnea patients?

Mendelson M, Tonini J, Tamisier R, Pépin JL, Lévy P, Wuyam B, Flore P
2019 Blood Heart and Circulation  
Purpose: The aim of this study was to compare fat oxidation and cardio-respiratory adaptations during exercise between non-obese OSA patients and controls matched for age, BMI and physical activity levels. Method: Twelve recently diagnosed non-obese severe OSA patients (apnea-hypopnea index=39.1±21.0 events/hr, body mass index, BMI=27.8±2.3 kg.m -2 ) and twelve controls matched for age, BMI and physical activity levels were included in the study. Subjects underwent polysomnography,
more » ... raphy, ultrasonography measurement of carotid intima-media thickness (CIMT) and biological measurements (lipid profile, glucose metabolism, hsCRP). Subjects performed a maximal progressive exercise test as well as a standardized exercise calorimetry test to assess maximal fat oxidation (MFO) and Lipoxmax. Result: OSA patients presented greater right CIMT, blood levels of free fatty acids and hsCRP. However, maximal exercise capacity, MFO and Lipoxmax did not differ between groups. Conclusion: Our results suggest that despite vascular remodeling indicating an increased cardiovascular risk, exercise capacity and fat oxidation are not altered in nonobese severe OSA patients when compared with controls matched for age, BMI and physical activity levels. Despite normal cardiorespiratory and metabolic exercise adaptations in non-obese OSA patients, exercise training should not be neglected to limit the well-known development of cardio-metabolic morbidity. Abbreviations: AHI : Apnea-hypopnea index, BMI: Body mass index, CIMT: carotid intima-media thickness, CPAP: Continuous positive airway pressure, FFA: free fatty acids, HOMA2-IR: Homoeostasis model assessment for insulin resistance, hsCRP: High sensitive c reactive protein, MFO: Maximal fat oxidation, OSA: Obstructive sleep apnea, VO 2peak : Peak aerobic capacity. Mendelson M (2019) Are fat oxidation and cardiorespiratory adaptations impaired during exercise in untreated non-obese severe obstructive sleep apnea patients? Volume 3: 2-5
doi:10.15761/bhc.1000152 fatcat:cxwjecsqyzb6hianhyja3d42ee