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Inhibitory Effect of Estrogen on Mammary Growth and Its Counteraction by Pituitary Isograft in Mice
1972
Endocrinologia Japonica
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Synopsis Mammary growth was markedly inhibited in mice by a single subcutaneous injection of 100 pg hexestrol dicaprylate despite the fact that the pituitary prolactin levels were significantly higher in these mice than in the intact controls. The degeneration of mammary gland was completely counteracted by the simultaneous isologous pituitary grafting, indicating that the additional supply of prolactin from the grafts overcame the inhibitory action of estrogen on mammary growth. These results
doi:10.1507/endocrj1954.19.107
pmid:5068028
fatcat:fwde4dbgtnh6ppnfekdjc4rthu