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Cell-cell interactions orchestrate organismal development, homeostasis and single-cell functions. When cells do not properly interact or improperly decode molecular messages, disease ensues. Thus, the identification and quantification of intercellular signalling pathways has become a common analysis performed across diverse disciplines. The expansion of protein-protein interaction databases and recent advances in RNA sequencing technologies have enabled routine analyses of intercellulardoi:10.1038/s41576-020-00292-x pmid:33168968 pmcid:PMC7649713 fatcat:27ur3qmwbvbe3ptqjcechg6v4a