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Cerebellar Granule Cell-Specific and Inducible Expression of Cre Recombinase in the Mouse
1999
Journal of Neuroscience
To develop a cell type-specific and temporal regulation system of gene targeting in the cerebellum, we used the NMDA-type glutamate receptor GluR⑀3 subunit gene and Cre recombinaseprogesterone receptor fusion (CrePR) gene in combination. Injection of the CrePR gene placed under the control of the 10 kb 5Ј region of the GluR⑀3 gene into C57BL/6 eggs yielded the ECP25 line that strongly expressed the CrePR mRNA selectively in the granule cells of the cerebellum. Using a transgenic mouse carrying
doi:10.1523/jneurosci.19-23-10318.1999
pmid:10575029
fatcat:aictgqbgb5c7jgu2jrglrt2thy