Internet Archive Scholar

Translational research into vascular wall function: regulatory effects of systemic and specific factors

Alexander V Maksimenko
2017 Journal of Translational Science  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (8.8 MB)
https://web.archive.org/web/20180719151700/http://www.oatext.com/pdf/JTS-3-180.pdf

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL. The file type is application/pdf.

Development of biomedical techniques has intensified the investigation of endothelial glycocalyx as an individual research object. The effect of vascular wall hydration on progression of pathological lesions, including atherosclerosis, has been revealed and examined. There is evidence that atherosclerosis is associated with water-sulfate and water-sodium exchange. The concept that atherosclerosis is initiated by deficiency of sulfur-containing compounds has been regarded. Glycocalyx protective
more » ... unction against damaging effect of oxidative stress on vascular wall is associated with accumulation and retention of antioxidants on luminal surface of blood vessel. The review deals with protective activity of antioxidant enzyme derivatives, computational methods to determine the principles of the glycocalyx functioning and modeling of the glycocalyx interaction with systemic and specific factors. A limiting influence of crosswind move from clinical practice to life science and contrariwise from life science to clinical practice on the development of translational medicine is emphasized. Abbreviations: Maksimenko AV (2017) Translational research into vascular wall function: regulatory effects of systemic and specific factors
doi:10.15761/jts.1000180 fatcat:l2ylyn2hi5dc3hapycpelms5ca
Citation

Alexander V Maksimenko. "Translational research into vascular wall function: regulatory effects of systemic and specific factors." Journal of Translational Science 3.3 (2017)