Osthole Improves Aspects of Spatial Performance in Ovariectomized Rats

Ming-Tsuen Hsieh, Chia-Ling Hsieh, Wen-Hsin Wang, Chia-Sheng Chen, Chun-Ju Lin, Chi-Rei Wu
2004 THE American journal of Chinese medicine  
The present study was designed to investigate the ameliorating effects of Cnidiuim monnieri L. Cusson (CM) and osthole, a constituent of CM, on the spatial performance deficit in scopolamine (SCOP)-treated or ovariectomized (OVA) rats. CM improved the deficit of spatial performance, and reversed the lower plasma estradiol levels caused by SCOP in female rats. In addition, osthole (3 and 10 mg/kg, sc) improved the performance deficit in OVA rats. It (10 and 30 µg/brain, icv) also improved the
more » ... formance deficit caused by SCOP in intact female rats, and at 30 µg/brain improved the deficit in OVA rats. However, osthole did not alter the latency swum to reach the visible target in SCOP-treated and OVA rats. Accordingly, we suggested that osthole is an active constituent of CM, and possesses ameliorating effects on the spatial performance deficits in SCOP-treated female rats or OVA rats. The action mechanism of the effects of osthole on performance deficits was related to the estrogen-like properties and activating the central cholinergic neuronal system.
doi:10.1142/s0192415x04001758 pmid:15154281 fatcat:i2mjsbpb7jhyblpaj7sxq4xrye