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Cdc2-mediated Inhibition of Epidermal Growth Factor Activation of the Extracellular Signal-regulated Kinase Pathway during Mitosis
Journal of Biological Chemistry
Inhibition of general transcription and translation occurs during mitosis to preserve the high energy requirements needed for the dynamic structural changes that are occurring at this time of the cell cycle. Although the mitotic kinase Cdc2 appears to directly phosphorylate and inhibit key proteins directly involved in transcription and translation, the role of Cdc2 in regulating upstream growth factor receptor-mediated signal transduction pathways is limited. In the present study, we examineddoi:10.1074/jbc.m414079200 pmid:15888452 fatcat:n645ui5ks5gcxiv5jddofww5ye