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Predicting novel histopathological microlesions in human epileptic brain through transcriptional clustering
2014
Brain
Although epilepsy is associated with a variety of abnormalities, exactly why some brain regions produce seizures and others do not is not known. We developed a method to identify cellular changes in human epileptic neocortex using transcriptional clustering. A paired analysis of high and low spiking tissues recorded in vivo from 15 patients predicted 11 cell-specific changes together with their 'cellular interactome'. These predictions were validated histologically revealing millimetre-sized
doi:10.1093/brain/awu350
pmid:25516101
pmcid:PMC4306820
fatcat:vnolbmblyvhuhje2btqz4sstra