Objective: To evaluate the incidence of risk of Mental Disorders (MD), Suicide and Quality of Life in medical students. Methods: This is a prospective cross-sectional study conducted at a Public Higher Education Institution of Medicine in Southern Brazil. Evaluation of 775 students who responded in person to Adult Self Repport (ASR) and WHOQOL-100, with individual return of results, orientation and mandatory referral for those with "Borderline" and "Clinical" scores and optional for those with

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... Normal" score. Results: The incidence of MD risk was 54.3% and suicide risk was 10.6%. Internalizing Problems were observed in 34.7% of cases and Externalizing Problems in 12.6%. Among the most frequent syndromes, Anxiety/Depression, Isolation and Attention were highlighted. "Poor" or "Moderate" Overall Quality of Life was observed in about 30%, associated with adaptive functioning and the presence of DSM-Oriented or ASR problems at "Clinical" level (p <0.001). The main variables for suicide risk were Anxiety/Depression Problems, Internalizing Problems, Thought Problems, and Antisocial Personality (p <0.001). "Clinical" Score for two or more Syndromes or Total Problems was selected as an independent variable for the risk of suicide, while the Spirituality and Psychological domains were appointed as protective (p <0.001). Conclusions: There was a high incidence of MD associated with poor quality of life and increased risk of suicide among medical students.