Hemodialysis is one of the most common treatments for renal patients. Despite the hemodialysis effect, these patients face a variety of physical and mental stressors. Therefore, the purpose of this study was to determine the relationship between resilience and perceived social support with hope in hemodialysis patients referred to a dialysis center in Shoushtar. Materials and Methods: The present study was an analytical cross-sectional study on 87 hemodialysis patients referred to the dialysis

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... enter of the Khatamolanbia Hospital in Shoushtar. Patients were selected using the convenience sampling method. The data gathering tools in this study included demographic information form, Herth Hope Index (HHI), Conner- Davidson Resilience Scale (CD-RIS) and Multidimensional Scale of Perceived Social Support (MSPSS). The data were analyzed using descriptive statistics (mean and standard deviation) as well as the Mann-Whitney, Kruskal-Wallis, Spearman correlation coefficient and linear regression tests in SPSS version 16. Results: The results showed that the mean age of the patients was 54.55 ± 17.12 year. Moreover, there was a direct and significant relationship between perceived social support (r=0.656, <0.001) and resilience (r=0.501, p<0.001) with hope. Conclusion: Authors suggest that health care providers increase life expectancy among these patients with hemodialysis using the necessary training in the resilience and social protection of patients and their families.