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Fixed drug eruption (FDE) is a type of cutaneous drug reaction that occurs at the same sites upon re-exposure to specific medications. Herein we discuss the case of a 23-year-old man with a FDE to fluconazole. Case synopsis A 23-year-old man presented with complaints of erythematous/edematous plaques in his right axilla and over his right lateral eyebrow area. He said that the plaques always appeared within 24 hours after he took his monthly dose of 300 mg of fluconazole for treatment offatcat:hxg4derftjaqbayq3a2p2l5eii