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5G, the most disruptive innovation, had played a significant role in the COVID-19 pandemic prevention and control. However, as a novel technology and context, we have little knowledge about how 5G enabled pandemic prevention and control. This study collected 212 cases and conducted qualitative research to explore how the 5G worked in prevention and control. Based on the concepts of materiality and affordance, we grounded two affordances of spatialization and de-spatialization from the data.doi:10.3390/ijerph19158965 pmid:35897336 pmcid:PMC9332237 fatcat:ok2hypmfkracrhl3ky3lmsjgxu