OrthoDB: the hierarchical catalog of eukaryotic orthologs

E. V. Kriventseva, N. Rahman, O. Espinosa, E. M. Zdobnov
2007 Nucleic Acids Research  
The concept of orthology is widely used to relate genes across different species using comparative genomics, and it provides the basis for inferring gene function. Here we present the web accessible OrthoDB database that catalogs groups of orthologous genes in a hierarchical manner, at each radiation of the species phylogeny, from more general groups to more fine-grained delineations between closely related species. We used a COG-like and Inparanoid-like ortholog delineation procedure on the
more » ... is of all-against-all Smith-Waterman sequence comparisons to analyze 58 eukaryotic genomes, focusing on vertebrates, insects and fungi to facilitate further comparative studies. The database is freely available at
doi:10.1093/nar/gkm845 pmid:17947323 pmcid:PMC2238902 fatcat:iwwdxbt3evcs5f73frxd6z4jbu