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Insulin resistance (IR) is pathogenic for type 2 diabetes and coronary artery disease (CAD). The K121Q polymorphism of the ENPP1/PC-1 gene is associated with IR. Our aim was to investigate the role of the 121Q variant on the risk of type 2 diabetes and CAD. Nondiabetic control subjects (n ؍ 638), type 2 diabetic patients without CAD (n ؍ 535), and type 2 diabetic patients with CAD (n ؍ 434) from Italy and the U.S. were studied. The proportion of 121Q carriers progressively increased indoi:10.2337/diabetes.54.10.3021 pmid:16186408 fatcat:vcmhaymrpneozjbct3grmnyldq