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Überleben pädiatrischer Patienten nach einem Rezidiv einer akuten myeloischen Leukämie nach erster allogener hämatopoetischer Stammzelltransplantation: eine retrospektive I-BFM Untersuchung an 333 Kindern [thesis]

Theodor Uden, Medizinische Hochschule Hannover Bibliothek, Martin Günther Sauer
2021

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Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P =< 0Á0001). Achievement of a subsequent remission impacted survival (P =< 0Á0001). For patients receiving a second transplant survival with or without achieving a
more » ... t remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0Á046) and donor choice (matched family vs. matched unrelated donor, P = 0Á029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.
doi:10.26068/mhhrpm/20210423-002 fatcat:d23nxsf2ibflfiid2spizas5l4
lang:de
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Theodor Uden, Medizinische Hochschule Hannover Bibliothek, Martin Günther Sauer. "Überleben pädiatrischer Patienten nach einem Rezidiv einer akuten myeloischen Leukämie nach erster allogener hämatopoetischer Stammzelltransplantation: eine retrospektive I-BFM Untersuchung an 333 Kindern." (2021)