TISIGNER.com: web services for improving recombinant protein production

Bikash K Bhandari, Chun Shen Lim, Paul P Gardner
2021 Nucleic Acids Research  
Experiments that are planned using accurate prediction algorithms will mitigate failures in recombinant protein production. We have developed TISIGNER (https://tisigner.com) with the aim of addressing technical challenges to recombinant protein production. We offer three web services, TIsigner (Translation Initiation coding region designer), SoDoPE (Soluble Domain for Protein Expression) and Razor, which are specialised in synonymous optimisation of recombinant protein expression, solubility
more » ... signal peptide analysis, respectively. Importantly, TIsigner, SoDoPE and Razor are linked, which allows users to switch between the tools when optimising genes of interest.
doi:10.1093/nar/gkab175 pmid:33744969 fatcat:hjujj7ajrrevfdfd6zuqxfc34e