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This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.doi:10.1159/000374050 pmid:25924624 fatcat:2friynteg5a2nnd4wi5lgnlkiu