ANTI-INFECTIVE POTENTIAL OF MORINDA CITRIFOLIA FRUIT EXTRACT

Research Article, Smita Nayak, Meena Chintamaneni, Sushma Mengi
unpublished
Morinda citrifolia Linn (Rubiaceae), a plant with reported immunostimulant properties was selected for studying its anti-infective potential. The hydroalcoholic extracts of M. citrifolia fruits were evaluated in rats for their role in attenuation of physiological changes occurring due to the onset of E. coli induced sepsis. Results obtained from in-vitro studies indicated that the extract did not exert any anti-bacterial effect. However, the in-vivo studies revealed the ability of the extract
more » ... ty of the extract to prevent alterations in four important physiological parameters namely-body temperature, pulse rate, breathing rate and WBC count. Our study indicates that the hydroalcoholic extract of Morinda citrifolia fruits is as effective as Gentamicin, a standard antibiotic used commonly for treatment of sepsis. This probably accounts for the widespread traditional usage of this plant as a febrifuge and anti-infective. Further studies need to be carried out to establish a correlation between its immunostimulant activity and anti-infective potential.
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