Cardiac evaluation from radioisotope dynamics

D Van Dyke, H O Anger, R W Sullivan, W R Vetter, Y Yano, H G Parker
1972 Journal of Nuclear Medicine  
The use of radioactive isotopes to obtain quanti tative information on the size of the blood-containing compartments in the cardiopulmonary circulation, and the rate of blood flow through these compart ments had its beginnings over 20 years ago (7). In the last 10 years there have been significant advances in available isotopes and methods of preparation (2), in rapid, high-resolution imaging devices (3) , and in quantitative area-of-interest recording tech niques. These advances have
more » ... nces have contributed to the rapid recent development in the field and to the method to be described here (4-7). According to Chapman et al (8) , "The ideal sys tem for following changes in ventricular volume is obviously one which is fully applicable to the freeliving organism, which requires no injection of any sort, and which can be used repeatedly over long periods of time without danger or discomfort to the subject. Such a system, if it ever becomes available, can hardly be based on roentgenographic principles." tt tÃ-t t t tft t t t f i i t i • i FIG. 1. Print from 80-lens camera negative showing two simul taneous sequential recordings of passage of """'Tc bolus through central circulation. Upper series of 40 pictures: starting time inter val, 0.5 sec/picture; exposure time, 0.5 sec/picture. Lower series of 40 pictures, starting time interval, 0.5 sec/picture; exposure time, 2 sec/picture, to allow collection of large number of dots per picture.
pmid:5041634 fatcat:2qok73sgprez3obwgiva2sy4we