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SALL4, the missing link between stem cells, development and cancer
2016
Gene
There is a growing body of evidence supporting that cancer cells share many similarities with embryonic stem cells (ESCs). For example, aggressive cancers and ESCs share a common gene expression signature that includes hundreds of genes. Since ESC genes are not present in most adult tissues, they could be ideal candidate targets for cancer-specific diagnosis and treatment. This is an exciting cancer-targeting model. The major hurdle to test this model is to identify the key factors/pathway(s)
doi:10.1016/j.gene.2016.02.019
pmid:26892498
pmcid:PMC4823161
fatcat:px7druzwozgnzhrprjqta4qpyi