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Effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells
2003
American Journal of Physiology. Heart and Circulatory Physiology
Although hypoxia induces heme oxygenase (HO)-1 protein and mRNA expression in many cell types, hypoxia has also been shown to decrease HO-1 mRNA and protein expression. We tested the hypothesis that 24-h preexposure to hypoxia in human placental preparations suppresses HO protein expression and enzymatic function. Immortalized HTR-8/SVneo first-trimester trophoblast cells and explants of normal human chorionic villi (CV) from term placentas were cultured for 24 h in 1%, 5%, or 20% O 2. HO
doi:10.1152/ajpheart.00655.2002
pmid:12578814
fatcat:thgaami5xvaj7nov7w566qwoke