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An enhanced version of Cochran-Armitage trend test for genome-wide association studies
2016
Meta Gene
Genome-wide association studies the evaluation of association between candidate gene and disease status is widely carried out using Cochran-Armitage trend test. However, only a small number of research papers have evaluated the distribution of p-values for the Cochran-Armitage trend test. In this paper, an enhanced version of Cochran-Armitage trend test based on bootstrap approach is introduced. The achieved results confirm that the distribution of p-values of the proposed approach fits better
doi:10.1016/j.mgene.2016.07.001
pmid:27617223
pmcid:PMC5006094
fatcat:pzurgh5jijhzhpmslfmj4ufxyy