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Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine
1982
Journal of Virology
Mutants of herpes simplex virus type 1 resistant to the antiviral drug 9-4-Darabinofuranosyladenine (araA) have been isolated and characterized. AraAresistant mutants can be isolated readily and appear at an appreciable frequency in low-passsage stocks of wild-type virus. Of 13 newly isolated mutants, at least 11 were also resistant to phosphonoacetic acid (PAA). Of four previously described PAA-resistant mutants, two exhibited substantial araA resistance. The araA resistance phenotype of one
doi:10.1128/jvi.41.3.909-918.1982
fatcat:xz27dm37zrashbtqzo7t6yrrn4