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Journal of Virology
Mutants of herpes simplex virus type 1 resistant to the antiviral drug 9-4-Darabinofuranosyladenine (araA) have been isolated and characterized. AraAresistant mutants can be isolated readily and appear at an appreciable frequency in low-passsage stocks of wild-type virus. Of 13 newly isolated mutants, at least 11 were also resistant to phosphonoacetic acid (PAA). Of four previously described PAA-resistant mutants, two exhibited substantial araA resistance. The araA resistance phenotype of onedoi:10.1128/jvi.41.3.909-918.1982 fatcat:xz27dm37zrashbtqzo7t6yrrn4