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Colloidal gold particles with functionalized organic shells were applied as novel selectin binders. The ligand shell was terminated with different monocyclic carbohydrate mimetics as simplified analogs of the sLe x unit found in biological selectin ligands. The multivalent presentation of the sulfated selectin binding epitopes on the gold particles led to extremely high binding affinities towards L-and P-selectin and IC 50 values in the subnanomolar range. Depending on the ring size of thedoi:10.1039/c1ob05583f pmid:21904758 fatcat:qnd3n6zs6rbvxgvwzmraqn3ipm