Importance of nitric oxide for local increases of blood flow in rat cerebellar cortex during electrical stimulation

N. Akgoren, M. Fabricius, M. Lauritzen
1994 Proceedings of the National Academy of Sciences of the United States of America  
The endothellum-derived relaxing factor, probably nitric oxide (NO), is a potent vasodilator that regulates the vascular tone in several vascular beds, inclu the brain. We explored the posibi that NO might be of importance for the increase of cerebral blood flow (CBF) a ited with activity of the well-efined neuronal circuits of the rat cerebellar cortex. Laser-loppler fiownry was used to measure increases of cerebellar blood flow evoked by trains of electrical stimulations of the dorsal
more » ... The evoked increases of CBF were frequency-dependent, being larger on than off the parallel fiber tracts, suggesting that conduction along parallel fibers and synaptic activation of target cells were important for the increase of CBF. This was verified experimentally since the evoked CBF increases were abolished by tetrodotoxin and reduced by 10 mM Mg2+ and selective angonit for non-N-methyl-D-aspartate receptors. The cer-
doi:10.1073/pnas.91.13.5903 pmid:7517038 pmcid:PMC44105 fatcat:klceopzkbzevpihbgjj3i7tutm