Ab-origin: An Improved Tool of Heavy Chain Rearrangement Analysis for Human Immunoglobulin [chapter]

Xiaojing Wang, Wu Wei, SiYuan Zheng, Z. W. Cao, Yixue Li
2007 Lecture Notes in Computer Science  
An improved tool to explore the origin of human immunoglobulin heavy chains, named Ab-origin, has been developed. It can analyze in detail the V-D-J joints from the rearranged sequence by searching against germline databases. In addition to the known information about antibody recombination, appropriate score system and restriction of searching location are also incorporated to improve computing performance. When compared with a newly developed software SoDA, Ab-origin performed much better in
more » ... oth accuracy and stability, with 2, 7 and 1 percent higher for V, D and J respectively. Though only taking the human heavy chain for an example here, the algorithm also suits for the analysis of all immunoglobulin and TCR sequences.
doi:10.1007/978-3-540-72586-2_52 fatcat:cin2po2eqredbalvvpk4uaobca