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DNA molecular combing-based replication fork directionality profiling
Nucleic Acids Research
The replication strategy of metazoan genomes is still unclear, mainly because definitive maps of replication origins are missing. High-throughput methods are based on population average and thus may exclusively identify efficient initiation sites, whereas inefficient origins go undetected. Single-molecule analyses of specific loci can detect both common and rare initiation events along the targeted regions. However, these usually concentrate on positioning individual events, which only gives andoi:10.1093/nar/gkab219 pmid:33836085 fatcat:nno5jtk3fvfbjiz77chbaou4vy