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The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors. [Cancer Res 2007;67(11):5064-6] Requests for reprints: Jeffrey W. Pollard, DMB,doi:10.1158/0008-5472.can-07-0912 pmid:17545580 fatcat:qzeht2qewbgorg7lum74sgoc4a