The endocytosis and intracellular fate of nanomedicines: Implication for rational design

Longfa Kou, Jin Sun, Yinglei Zhai, Zhonggui He
2013 Asian Journal of Pharmaceutical Sciences  
Endocytosis Transcytosis Organelle target Clathrin Caveolae a b s t r a c t Nanomedicines employ multiple endocytic pathways to enter cells. Their following fate is interesting, but it is not sufficient understood currently. This review introduces the endocytic pathways, presents new technologies to confirm the specific endocytic pathways and discusses factors for pathway selection. In addition, some intriguing implication about nanomedicine design based on endocytosis will also be discussed at
more » ... lso be discussed at the end. This review may provide new thoughts for the design of novel multifunctional nanomedicines.
doi:10.1016/j.ajps.2013.07.001 fatcat:sqdmzcg5pfczbgszrmgcaopwlm