Renal Denervation: Paradise Lost? Paradise Regained?

Deepak Padmanabhan, Ameesh Isath, Bernard Gersh, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, Department of Internal Medicine, Mount Sinai St Luke's Hospital, New York, NY, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN
2018 US Cardiology Review  
Renal denervation is a relatively recent concept whose initial promising results suffered a setback following the SYMPLICITY 3 trial, which did not show a significant blood pressure-lowering effect in comparison to sham. In this review article, we begin with the history including the physiological basis behind the concept of renal denervation. Furthermore, we review the literature in support of renal denervation, including the recently published SPYRAL HTN-OFF MED, which demonstrated
more » ... blood pressure reduction in the absence of antihypertensive medication. We further touch upon the potential pitfalls and possible future directions of renal denervation.
doi:10.15420/usc.2018.1.2 fatcat:3qmfxts4zrfhje3ual4eupqu2i