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Evidence supports the systemic inflammation in obesity and insulin resistance. Apelin is secreted by adipose tissue and plays an important role in the inflammation process. The present study aimed to examine the effect of 8 weeks aerobic training on plasma Apelin in male rats treated with Nitro-L-Arginine-Methyl Ester (L-NAME). Materials and Methods: In this experimental study male Wistar rats (n=24, age 20 months) were randomly assigned into four groups: Control, Training, TrainingS+L-NAME andfatcat:77vlufxcvre7nfvlppmfuql224