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Yeast Augmented Network Analysis (YANA): a new systems approach to identify therapeutic targets for human genetic diseases
2014
F1000Research
Genetic interaction networks that underlie most human diseases are highly complex and poorly defined. Better-defined networks will allow identification of a greater number of therapeutic targets. Here we introduce our east ugmented etwork nalysis (YANA) approach Y A N A and test it with the X-linked spinal muscular atrophy (SMA) disease gene First, we express and a mutant variant in fission yeast and use UBA1. UBA1 high-throughput methods to identify fission yeast genetic modifiers of . UBA1
doi:10.12688/f1000research.4484
fatcat:wuvhj2n2qbcangvwqy5nn72o7q