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Expression and Function of Inositol 1,4,5-Trisphosphate Receptors in the Heart
2015
Biophysical Journal
during EADs; and 5) the transition from phase-2 to phase-3 EADs. We show that: 1) increasing RyR leakiness and/or SR Ca uptake rate promotes DADs, but can either suppress or potentiate EADs; 2) EADs can occur after a long plateau phase, and random opening of L-type Ca channels in plateau voltage prevents Ca waves and thus Ca oscillations in the long plateau phase in which both cytosolic and SR Ca remain high; 3) two distinct DAD mechanisms exist_a non-Ca wave mediated spontaneous SR Ca release
doi:10.1016/j.bpj.2014.11.1449
fatcat:sxsj3qjzcnbc7hc2agpkahhjiu