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Determining the Mutation Bias of Favipiravir in Influenza Using Next-generation Sequencing
[article]
2018
bioRxiv
pre-print
Favipiravir is a broad spectrum antiviral drug that may be used to treat influenza. Previous research has identified that favipiravir likely acts as a mutagen but the precise mutation bias that favipiravir induces in influenza virus RNAs has not been described. Here, we use next-generation sequencing (NGS) with barcoding of individual RNA molecules to accurately and quantitatively detect favipiravir-induced mutations and to sample orders of magnitude more mutations than would be possible
doi:10.1101/375378
fatcat:6jsdxfvq55ebjmdz6ulql2zn6i