This study proposes an improved method based on a nonlinear parametric model for intensity profile to increase the edge localization accuracy in medical images gathered from different imaging modalities. The edge model consists of three parameters associated with an edge point. It also takes into account local background intensity, noise, and blurring. The Marquardt-Levenberg algorithm is used to estimate the parameters because of its accuracy and good convergence rate. Performance of the

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... ed method is tested quantitatively by comparing the results with those of the well-known active contour method on synthetic vessel images. Qualitative comparisons on real MRI, coronary angiography, CT, ultrasound, and retinal images showed that the proposed method accurately estimates edges in medical images.