Target Of Rapamycin pathway in the white-rot fungus Phanerochaete chrysosporium

Duy Vuong Nguyen, Thomas Roret, Antonio Fernandez-Gonzalez, Annegret Kohler, Mélanie Morel-Rouhier, Eric Gelhaye, Rodnay Sormani, Daniel Cullen
2020 PLoS ONE  
The Target Of Rapamycin (TOR) signaling pathway is known to regulate growth in response to nutrient availability and stress in eukaryotic cells. In the present study, we have investigated the TOR pathway in the white-rot fungus Phanerochaete chrysosporium. Inhibition of TOR activity by rapamycin affects conidia germination and hyphal growth highlighting the conserved mechanism of susceptibility to rapamycin. Interestingly, the secreted protein content is also affected by the rapamycin
more » ... Finally, homologs of the components of TOR pathway can be identified in P. chrysosporium. Altogether, those results indicate that the TOR pathway of P. chrysosporium plays a central role in this fungus.
doi:10.1371/journal.pone.0224776 pmid:32078630 pmcid:PMC7032718 fatcat:jbesvnpnmfhgjcs7q2dezredoi